Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29543801 | 0.88 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2HTTKDM4ECHRNB2 | |
| SCHEMBL29542935 | 0.82 | PARP1 (0.44) | ALDH1A1SMN1; SMN2HTTKDM4EKDR | |
| SCHEMBL6779138 | 0.73 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTCHRNB2CHRNB4 | |
| SCHEMBL24335590 | 0.73 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2HTTMAPTRAB9A | |
| SCHEMBL24336250 | 0.73 | NPC1 (0.59) | ALDH1A1SMN1; SMN2HTTMAPTRAB9A | |
| SCHEMBL24335574 | 0.72 | LMNA (0.58) | ALDH1A1SMN1; SMN2HTTRAB9ATYK2 | |
| SCHEMBL24336238 | 0.72 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2HTTMAPTRAB9A | |
| SCHEMBL29543184 | 0.71 | PARP1 (0.41) | ALDH1A1SMN1; SMN2HTTKDM4EKDR | |
| SCHEMBL24335934 | 0.71 | SMN1; SMN2 (0.79) | ALDH1A1SMN1; SMN2HTTMAPTRAB9A | |
| SCHEMBL29542980 | 0.71 | HDAC1 (0.38) | ALDH1A1SMN1; SMN2HTTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214197-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | Nura Bio, Inc. (US) | 2023-07-26 | — | — | EP | disclosed |
| WO-2022060812-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. (US) | 2022-03-24 | — | — | WO | disclosed |