Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21566290 | 1.00 | SNCA (0.35) | SNCAFLT1GRIN3BGRIN1GRIN2C | |
| SCHEMBL105732 | 0.77 | FLT1 (0.33) | FLT1GRIN3BGRIN1GRIN2C | |
| SCHEMBL15397430 | 0.77 | RIPK2 (0.36) | GRIN3BGRIN1GRIN2CKDM4E | |
| SCHEMBL29767078 | 0.77 | FLT1 (0.33) | FLT1GRIN3BGRIN1GRIN2C | |
| SCHEMBL29560181 | 0.74 | NOS3 (0.35) | GRIN3BGRIN1GRIN2CKDM4EMEN1 | |
| SCHEMBL22866543 | 0.74 | NOS3 (0.35) | GRIN3BGRIN1GRIN2CKDM4EMEN1 | |
| SCHEMBL31612698 | 0.73 | GRIN3B (0.34) | GRIN3BGRIN1GRIN2C | |
| SCHEMBL13802202 | 0.69 | HSD17B10 (0.47) | MEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL8268309 | 0.68 | NISCH (0.35) | FLT1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1490718 | 0.67 | ALK (0.50) | KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| EP-3994139-A1 | EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS | Effector Therapeutics Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| WO-2022072634-A1 | BICYCLIC COMPOUNDS FOR USE IN THE TREATMENT CANCER | SCORPION THERAPEUTICS, INC. (US) | 2022-04-07 | — | — | WO | disclosed |
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |