Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29544791 | 0.79 | MET (0.39) | GSK3BDYRK1AATRMAPK1IGF1R | |
| SCHEMBL29545017 | 0.79 | CYP2C9 (0.49) | GSK3BDYRK1AMAPK1CDK9EGFR | |
| SCHEMBL1192656 | 0.76 | ATR (0.50) | GSK3BDYRK1AATRMAP4K4IGF1R | |
| SCHEMBL30953487 | 0.76 | ATR (0.50) | GSK3BDYRK1AATRMAP4K4IGF1R | |
| SCHEMBL30381790 | 0.75 | GSK3B (0.50) | GSK3BDYRK1AATRMAPK1SYK | |
| SCHEMBL828560 | 0.74 | TP53 (0.51) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL23510740 | 0.73 | GSK3B (0.45) | GSK3BDYRK1AATRMAPK1IGF1R | |
| SCHEMBL31637747 | 0.72 | GSK3B (0.47) | GSK3BDYRK1AATRMAPK1IGF1R | |
| SCHEMBL7909650 | 0.72 | ATR (0.46) | GSK3BDYRK1AATRMAP4K4IGF1R | |
| SCHEMBL1133582 | 0.72 | ATR (0.46) | GSK3BDYRK1AATRIGF1RCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022072634-A1 | BICYCLIC COMPOUNDS FOR USE IN THE TREATMENT CANCER | SCORPION THERAPEUTICS, INC. (US) | 2022-04-07 | — | — | WO | disclosed |