Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30981705 | 0.86 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL428202 | 0.79 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL422508 | 0.77 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL30981706 | 0.74 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL425218 | 0.74 | PAX8 (0.51) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL30701096 | 0.73 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL19318761 | 0.73 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL29546690 | 0.73 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL28393974 | 0.72 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL22036737 | 0.72 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860994-B1 | TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE | UNIV BRITISH COLUMBIA (CA) | 2024-08-14 | — | — | EP | disclosed |
| US-20220106304-A1 | Transcription Factor BRN2 Inhibitory Compounds as Therapeutics and Methods for Their Use | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2022-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106304-A1 | Transcription Factor BRN2 Inhibitory Compounds as Therapeutics and Methods for Their Use | BRDT, CBFB, CREBBP | HSP90AA1 2946/4885HSP90AB1 3173/4885PIK3R1 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.