Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.30 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546533 | 0.91 | PARP1 (0.39) | PARP1MPOTLR9TLR8TLR7 | |
| SCHEMBL6431313 | 0.74 | CA1 (0.38) | — | |
| Trifluoroacetic Acid SCHEMBL29545865 | 0.73 | CHRNB2 (0.32) | SCDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| Trifluoroacetic Acid SCHEMBL27195372 | 0.73 | PDK2 (0.37) | HTR4 | |
| Trifluoroacetic Acid SCHEMBL30848776 | 0.70 | CHRNA7 (0.34) | — | |
| SCHEMBL12255455 | 0.69 | MPO (0.43) | MPOTLR9TLR8TLR7 | |
| Trifluoroacetic Acid SCHEMBL23779156 | 0.68 | KDM4E (0.58) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL30478376 | 0.68 | KDM4E (0.58) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL3450626 | 0.68 | KDM4E (0.58) | PARP1 | |
| Trifluoroacetic Acid SCHEMBL27034351 | 0.67 | HRH4 (0.36) | HRH4HRH3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-A1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | Mission Therapeutics Limited (GB) | 2023-04-05 | — | — | EP | disclosed |
| WO-2022084479-A1 | N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2022-04-28 | — | — | WO | disclosed |