Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30408161 | 0.90 | IRAK4 (0.40) | IRAK4PDE10ADPP4FAPDPP8 | |
| SCHEMBL31211966 | 0.74 | JAK2 (0.39) | IRAK4JAK2 | |
| SCHEMBL31211838 | 0.73 | JAK2 (0.40) | IRAK4JAK2 | |
| Trifluoroacetic Acid SCHEMBL19875882 | 0.72 | IRAK4 (0.41) | IRAK4 | |
| SCHEMBL30267250 | 0.69 | JAK2 (0.54) | IRAK4PDE10AJAK2JAK3 | |
| SCHEMBL31211952 | 0.68 | L3MBTL1 (0.36) | JAK2JAK3HPGDSMN1; SMN2 | |
| SCHEMBL29767995 | 0.68 | JAK2 (0.43) | IRAK4MAPK1JAK2JAK3PIK3CD | |
| SCHEMBL31061409 | 0.67 | IRAK4 (0.40) | IRAK4JAK2JAK3HPGDPIK3CD | |
| SCHEMBL17657041 | 0.67 | PIK3CG (0.45) | IRAK4JAK2JAK3PIK3CDPIK3R2 | |
| SCHEMBL31211879 | 0.67 | HTR3A (0.37) | HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232059-A1 | DOUBLE DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087216-A1 | DOUBLE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |