Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20956992 | 0.86 | TNIK (0.56) | PGRTNIKCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL24314993 | 0.83 | CYP1A2 (0.70) | PGRPDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL8154135 | 0.79 | PARP10 (0.69) | PGRCHEK1MAPKAPK2CD274GRM5 | |
| SCHEMBL5999174 | 0.76 | PDE3B (0.59) | PDE3BPDE3AGRM5 | |
| SCHEMBL1883042 | 0.76 | CYP11B1 (0.76) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL4889182 | 0.72 | KIF11 (0.70) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL31083671 | 0.71 | CD274 (0.81) | CD274NISCH | |
| SCHEMBL25405671 | 0.71 | CD274 (0.81) | CD274NISCH | |
| SCHEMBL4406856 | 0.70 | CRBN (0.57) | PGRPDE3BPDE3ACHEK1BRD4 | |
| SCHEMBL5225707 | 0.70 | PGR (1.00) | PGRPDE3BPDE3ACHEK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086892-A1 | INTERLEUKIN 4 (IL4)-INDUCED GENE 1 INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2022-04-28 | — | — | WO | disclosed |