Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 8/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31205138 | 0.75 | RIPK1 (0.48) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL30062504 | 0.74 | KDR (0.36) | RIPK1CDK8CDK7PLK4DCLK1 | |
| SCHEMBL21958557 | 0.74 | KDR (0.36) | RIPK1CDK8CDK7PLK4DCLK1 | |
| SCHEMBL30824076 | 0.73 | HDAC6 (0.45) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL21358965 | 0.73 | HDAC6 (0.45) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL5100708 | 0.73 | RIPK1 (0.54) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL6364189 | 0.73 | HTT (0.35) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL26538899 | 0.71 | FGFR1 (0.38) | RIPK1CDK8HTTKDRPDPK1 | |
| SCHEMBL30632797 | 0.70 | PIM1 (0.39) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL20674174 | 0.67 | RIPK1 (0.44) | RIPK1CDK8CDK7CCNT1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022083560-A1 | TYK2 SELECTIVE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2022-04-28 | — | — | WO | disclosed |