Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.37 |
| ▸ | PDE2A | O00408 | 5/20 | 0.37 |
| ▸ | PDE5A | O76074 | 4/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20128587 | 1.00 | MAPT (0.39) | MAPTCYP11B2CYP11B1NPC1POLB | |
| SCHEMBL20128572 | 0.88 | LIMK1 (0.39) | NPC1POLBGAARAB9ARXFP1 | |
| SCHEMBL20129215 | 0.87 | CYP11B2 (0.44) | MAPTCYP11B2CYP11B1NPC1POLB | |
| SCHEMBL20128561 | 0.84 | METAP2 (0.42) | CYP11B2CYP11B1 | |
| SCHEMBL14134198 | 0.80 | MAPT (0.48) | MAPTCYP11B2NPC1POLBGAA | |
| SCHEMBL29547590 | 0.80 | MAPT (0.48) | MAPTCYP11B2NPC1POLBGAA | |
| SCHEMBL27097921 | 0.77 | EGLN1 (0.34) | MAPTNPC1RAB9ARXFP1 | |
| SCHEMBL29547669 | 0.77 | EGLN1 (0.34) | MAPTNPC1RAB9ARXFP1 | |
| SCHEMBL22906811 | 0.71 | GRIN1 (0.36) | GRIN1GRIN2B | |
| SCHEMBL20128576 | 0.70 | MAPT (0.47) | MAPTNPC1POLBGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954801-A | TAU protein targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114867727-B | TAU protein targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2025-02-21 | — | — | CN | disclosed |
| CN-114867727-A | TAU protein targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| EP-3999182-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |