Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24270088 | 1.00 | ALDH1A1 (0.31) | ALDH1A1MAPK1 | |
| SCHEMBL24269731 | 0.80 | ALDH1A1 (0.31) | ALDH1A1MAPK1 | |
| SCHEMBL12815868 | 0.76 | ALDH1A1 (0.37) | ALDH1A1MAPK1 | |
| SCHEMBL24269980 | 0.72 | ALDH1A1 (0.34) | ALDH1A1MAPK1 | |
| SCHEMBL8757205 | 0.70 | CYP2A6 (0.38) | ALDH1A1MAPK1 | |
| SCHEMBL8983833 | 0.69 | ACHE (0.44) | ALDH1A1MAPK1 | |
| SCHEMBL8755288 | 0.67 | ACHE (0.40) | ALDH1A1 | |
| SCHEMBL13429746 | 0.67 | ALDH1A1 (0.33) | ALDH1A1MAPK1 | |
| SCHEMBL249769 | 0.67 | — | — | |
| SCHEMBL156099 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624131-A | 3- [ (1H-pyrazol-4-yl) oxy ] pyrazin-2-amine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117624130-A | 3- [ (1H-pyrazol-4-yl) oxy ] pyrazin-2-amine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-116323565-A | 3- [ (1H-pyrazol-4-yl) oxy ] pyrazin-2-amine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2022068848-A1 | 3-[(1H-PYRAZOL-4-YL)OXY]PYRAZIN-2-AMINE COMPOUNDS AS HPK1 INHIBITOR AND USE THEREOF | BEIGENE, LTD. (KY) | 2022-04-07 | — | — | WO | disclosed |