Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29548176 | 1.00 | HDAC8 (0.37) | HDAC8NR1H2ABCB1HSD17B10MAPK1 | |
| SCHEMBL16635559 | 0.92 | IMPDH2 (0.39) | HDAC8NR1H2ABCB1HSD17B10MAPK1 | |
| SCHEMBL16647818 | 0.92 | IMPDH2 (0.39) | HDAC8NR1H2ABCB1HSD17B10MAPK1 | |
| SCHEMBL16774511 | 0.89 | HSD17B10 (0.39) | HDAC8NR1H2ABCB1HSD17B10SMN1; SMN2 | |
| SCHEMBL18610732 | 0.85 | SPHK1 (0.35) | HDAC8NR1H2ABCB1SMN1; SMN2SPHK1 | |
| SCHEMBL16803406 | 0.85 | SPHK1 (0.35) | HDAC8NR1H2ABCB1SMN1; SMN2SPHK1 | |
| SCHEMBL3512985 | 0.82 | KMT2A (0.34) | HDAC8HSD17B10IMPDH2SPHK1MEN1 | |
| SCHEMBL13967436 | 0.81 | FKBP1A (0.43) | ABCB1 | |
| SCHEMBL12480719 | 0.81 | FKBP1A (0.43) | ABCB1 | |
| SCHEMBL2380326 | 0.81 | IMPDH2 (0.39) | HDAC8NR1H2HSD17B10MAPK1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416199-A1 | INHIBITORS OF AMINO ACID TRANSPORT | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-12-28 | — | — | US | disclosed |
| WO-2022087630-A1 | INHIBITORS OF AMINO ACID TRANSPORT | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416199-A1 | INHIBITORS OF AMINO ACID TRANSPORT | SLC1A5, SLC7A1, SLC7A5 | HDAC8 3071/4885NR1H2 2000/4885ABCB1 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.