Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Acetophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenone SCHEMBL27552979 | 0.89 | CES2 (0.57) | NR4A2SMN1; SMN2MAPTALDH1A1LMNA | |
| Acetophenone SCHEMBL27462873 | 0.87 | MAPT (0.71) | SMN1; SMN2MAPTALDH1A1LMNACYP2C19 | |
| Acetophenone SCHEMBL719033 | 0.87 | MAPT (0.71) | SMN1; SMN2MAPTALDH1A1LMNACYP2C19 | |
| Acetophenone SCHEMBL1450855 | 0.87 | — | — | |
| Acetophenone SCHEMBL30537005 | 0.87 | — | — | |
| Acetophenone SCHEMBL30537000 | 0.87 | — | — | |
| Acetophenone SCHEMBL737 | 0.87 | — | — | |
| Acetophenone SCHEMBL16745259 | 0.87 | — | — | |
| Acetophenone SCHEMBL4730064 | 0.86 | SMN1; SMN2 (0.58) | NR4A2SMN1; SMN2MAPTALDH1A1LMNA | |
| Acetophenone SCHEMBL11649558 | 0.85 | MAPT (0.68) | SMN1; SMN2MAPTALDH1A1LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022071387-A1 | POLARIZING FILM, OPTICAL FILM, AND IMAGE DISPLAY DEVICE | 日東電工株式会社 | 2022-04-07 | — | — | WO | disclosed |