Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | KIF5B | P33176 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 14/20 | 0.41 |
| ▸ | ABL1 | P00519 | 13/20 | 0.41 |
| ▸ | EGFR | P00533 | 12/20 | 0.41 |
| ▸ | KDR | P35968 | 11/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.41 |
| ▸ | HCK | P08631 | 10/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.41 |
| ▸ | MTOR | P42345 | 10/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.41 |
| ▸ | PRKDC | P78527 | 10/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552528 | 0.91 | RET (0.43) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL31523756 | 0.79 | RET (0.48) | RETKIF5BKDR | |
| SCHEMBL24458389 | 0.79 | RET (0.48) | RETKIF5BKDR | |
| SCHEMBL24458601 | 0.78 | RET (0.49) | RETKIF5BKDR | |
| SCHEMBL24459026 | 0.78 | SRC (0.50) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL24458871 | 0.77 | RET (0.47) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL24458853 | 0.77 | RET (0.47) | RETKIF5BSRCABL1EGFR | |
| SCHEMBL24458900 | 0.77 | RET (0.46) | RETKIF5BKDR | |
| SCHEMBL24458503 | 0.76 | RET (0.45) | RETKIF5BKDR | |
| SCHEMBL24458531 | 0.76 | RET (0.45) | RETKIF5BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4247816-A1 | SRC INHIBITORS AND USES THEREOF | Relay Therapeutics, Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2022109551-A1 | SRC INHIBITORS AND USES THEREOF | RELAY THERAPEUTICS, INC. (US) | 2022-05-27 | — | — | WO | disclosed |