Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NPR3 | P17342 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359228 | 0.90 | SYK (0.40) | SYKCNR1KMT2ALMNAMAPT | |
| SCHEMBL29922807 | 0.90 | SYK (0.40) | SYKCNR1KMT2ALMNAMAPT | |
| SCHEMBL29552064 | 0.81 | MEN1 (0.41) | CNR1KMT2ALMNAMAPTRIPK1 | |
| SCHEMBL29552942 | 0.81 | TYK2 (0.41) | NPR3 | |
| SCHEMBL29552492 | 0.80 | SYK (0.46) | SYKCNR1KMT2ALMNAMAPT | |
| SCHEMBL29551926 | 0.77 | SYK (0.40) | SYKKMT2ALMNA | |
| SCHEMBL28362796 | 0.76 | NPC1 (0.41) | SYKCNR1KMT2ALMNARIPK1 | |
| SCHEMBL29552243 | 0.76 | ABCB1 (0.47) | SYKKMT2AMAPTALDH1A1 | |
| SCHEMBL29551896 | 0.75 | EHMT2 (0.47) | SYKKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL29552431 | 0.73 | SYK (0.48) | SYKKMT2ALMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |