Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 4/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28884124 | 0.79 | TYK2 (0.51) | MAP4K1BRD4CCNKCCND3CDK9 | |
| SCHEMBL28358862 | 0.78 | JAK2 (0.62) | MAP4K1CDK9CDK6JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL28362697 | 0.77 | JAK2 (0.61) | MAP4K1CDK9CDK6JAK2JAK1 | |
| SCHEMBL28359109 | 0.77 | JAK2 (0.50) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29552282 | 0.77 | JAK2 (0.50) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922646 | 0.76 | BRD4 (0.36) | CTSCMAP4K1HTR3ABRD4CCNK | |
| Hydrochloric Acid SCHEMBL29922747 | 0.75 | JAK2 (0.42) | MAP4K1CDK9CDK6JAK2JAK1 | |
| SCHEMBL29552914 | 0.73 | TYK2 (0.48) | CTSCCCND3CDK9CDK6JAK2 | |
| SCHEMBL29552318 | 0.70 | MAPK6 (0.43) | CDK6JAK2JAK1JAK3NTRK1 | |
| SCHEMBL27306274 | 0.64 | HTR3A (0.50) | MAP4K1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |