Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.54 |
| ▸ | JAK2 | O60674 | 12/20 | 0.54 |
| ▸ | JAK1 | P23458 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 6/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358955 | 0.89 | JAK2 (0.57) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551804 | 0.89 | JAK2 (0.42) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29922752 | 0.86 | JAK2 (0.49) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29552283 | 0.86 | JAK2 (0.49) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28359058 | 0.86 | JAK2 (0.49) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28359027 | 0.83 | JAK2 (0.54) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29551767 | 0.82 | JAK2 (0.54) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551888 | 0.81 | JAK2 (0.59) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL28359236 | 0.79 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29552249 | 0.79 | TYK2 (0.58) | TYK2JAK2JAK1JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |