Lappalone

Lappalone

SCHEMBL29554118

C=C1CC[C@H]2C(=C)CC[C@@H]3[C@H](OC(=O)[C@@]3(O)CC(C)=O)[C@@H]12

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PTPN1 P18031 1/20 0.31
▸ CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19361211 0.85 CYP3A4 (0.30) CYP3A4
SCHEMBL31169568 0.74 — —
SCHEMBL31169570 0.74 — —
SCHEMBL12516833 0.71 — —
SCHEMBL12459505 0.68 CYP3A4 (0.31) CYP3A4
SCHEMBL12459119 0.67 CYP3A4 (0.32) CYP3A4
Dehydrocostuslactone SCHEMBL31029489 0.62 CYP19A1 (0.46) CYP3A4
Dehydrocostuslactone SCHEMBL699070 0.62 CYP19A1 (0.46) CYP3A4
Mokko Lactone SCHEMBL29409720 0.61 MEN1 (0.42) —
Mokko Lactone SCHEMBL30171369 0.61 MEN1 (0.42) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109744-A1 AMYLOID PEPTIDE VARIANTS LOYOLA MARYMOUNT UNIV (US) 2026-04-23 — — US disclosed
EP-4686478-A1 QBP1 FOR USE IN THE TREATMENT AND/OR PREVENTION OF TYPE 2 DIABETES Consejo Superior de Investigaciones Científicas (CSIC) (ES) 2026-02-04 — — EP disclosed
EP-4686725-A1 AMYLOID INHIBITORY PEPTIDES Technische Universität München, in Vertretung des Freistaats Bayern (DE) 2026-02-04 — — EP disclosed
US-12522635-B2 Amyloid peptide variants LOYOLA MARYMOUNT UNIVERSITY (US) 2026-01-13 — — US disclosed
US-12336987-B2 Quinoline amides and methods of using same YALE UNIVERSITY (US) 2025-06-24 — — US disclosed
CN-120136187-A Ternary positive electrode material, preparation method thereof and electrochemical device 南通瑞翔新材料有限公司 2025-06-13 — — CN disclosed
US-20250161408-A1 PEPTIDIC INHIBITORS OF AMYLOID SELF- AND CROSS-ASSEMBLY LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) 2025-05-22 — — US disclosed
US-20250026838-A1 METHODS OF PREVENTING PROTEIN AGGREGATION TRUEBINDING, INC. 2025-01-23 — — US disclosed
CN-113679726-B Application of red sage root extract and quinone compound in resisting coronavirus 上海科技大学 2025-01-10 — — CN disclosed
EP-4482852-A1 PEPTIDIC INHIBITORS OF AMYLOID SELF- AND CROSS-ASSEMBLY Technische Universität München (DE) 2025-01-01 — — EP disclosed
CN-112424225-B anti-PD-L1 antibodies and uses thereof 桂林三金药业股份有限公司 2023-08-11 — — CN disclosed
CN-115947991-A Amorphous phase polypropylene composition with strong lubrication and high yield elongation and preparation method thereof 重庆会通科技有限公司 2023-04-11 — — CN disclosed
US-20230095144-A1 AMYLOID INHIBITORY PEPTIDES Technische Universität München (DE) 2023-03-30 — — US disclosed
EP-3368505-B1 QUINOLINE AMIDES AND METHODS OF USING SAME UNIV YALE (US) 2023-02-22 — — EP disclosed
WO-2023288252-A1 METHODS OF PREVENTING PROTEIN AGGREGATION TRUEBINDING, INC. (US) 2023-01-19 — — WO disclosed
CN-115361961-A Method for preventing or treating pancreatic dysfunction or diabetes by up-regulating human cathepsin LL-37 to inhibit islet amyloid polypeptide (IAPP) self-assembly 斯坦福大学托管董事会 2022-11-18 — — CN disclosed
US-11498943-B2 Amyloid inhibitory peptides Technische Universität München (DE) 2022-11-15 — — US disclosed
CN-113178614-B Composite solid electrolyte, solid lithium battery and preparation method 深圳市合壹新能技术有限公司 2022-11-04 — — CN disclosed
CN-114830374-A Method for manufacturing or recycling member for electrochemical device, method for manufacturing electrochemical device, member for electrochemical device, and electrochemical device 日本瑞翁株式会社 2022-07-29 — — CN disclosed
US-20220119468-A1 AMYLOID PEPTIDE VARIANTS LOYOLA MARYMOUNT UNIVERSITY 2022-04-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230095144-A1 AMYLOID INHIBITORY PEPTIDES IAPP, APP, APBA1 PTPN1 3112/4885CYP3A4 4855/4885
US-20260109744-A1 AMYLOID PEPTIDE VARIANTS IAPP, APP, SPPL2B PTPN1 966/4885CYP3A4 4426/4885
US-12336987-B2 Quinoline amides and methods of using same IAPP, AMY2A, APP PTPN1 3722/4885CYP3A4 3924/4885
US-11498943-B2 Amyloid inhibitory peptides IAPP, APP, APBA1 PTPN1 3112/4885CYP3A4 4855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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