Dehydrocostuslactone

Dehydrocostuslactone

SCHEMBL699070

C=C1CC[C@H]2C(=C)CC[C@H]3C(=C)C(=O)O[C@@H]3[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP19A1 P11511 3/20 0.46
▸ PKM P14618 6/20 0.43
▸ NLRP3 Q96P20 2/20 0.43
▸ ALDH1A1 P00352 4/20 0.41
▸ LMNA P02545 3/20 0.41
▸ TP53 P04637 3/20 0.41
▸ CYP3A4 P08684 3/20 0.41
▸ NFKB1 P19838 2/20 0.41
▸ CYP1A2 P05177 2/20 0.41
▸ STAT6 P42226 2/20 0.41
▸ MAPT P10636 2/20 0.41
▸ MEN1 O00255 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ CASP1 P29466 1/20 0.41
▸ PTGS2 P35354 1/20 0.41
▸ NFKB2 Q00653 1/20 0.41
▸ RELA Q04206 1/20 0.41
▸ CYP2D6 P10635 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dehydrocostuslactone SCHEMBL31029489 1.00 CYP19A1 (0.46) CYP19A1PKMNLRP3ALDH1A1LMNA
Dehydrocostuslactone SCHEMBL936050 1.00 CYP19A1 (0.46) CYP19A1PKMNLRP3ALDH1A1LMNA
Dehydrozaluzanin C SCHEMBL17214360 0.83 CYP19A1 (0.42) CYP19A1PKMNLRP3ALDH1A1LMNA
Isozaluzanin C SCHEMBL24453721 0.80 PKM (0.40) CYP19A1PKMNLRP3ALDH1A1LMNA
Isozaluzanin C SCHEMBL17214374 0.80 PKM (0.40) CYP19A1PKMNLRP3ALDH1A1LMNA
Eremanthin SCHEMBL9516039 0.79 CYP19A1 (0.56) CYP19A1PKMNLRP3ALDH1A1LMNA
SCHEMBL22305504 0.73 PTGS2 (0.40) CYP19A1PKMNLRP3CYP3A4PTGS2
SCHEMBL22305507 0.72 PKM (0.41) CYP19A1PKMNLRP3ALDH1A1LMNA
SCHEMBL17147746 0.71 PKM (0.55) CYP19A1PKMNLRP3ALDH1A1LMNA
SCHEMBL17147754 0.71 PKM (0.55) CYP19A1PKMNLRP3ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 748 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122084810-A Establishing method of fingerprint spectrum of oil for inducing resuscitation and saving heart and detecting method of component content — 2026-05-26 — — CN claimed
CN-122005545-A Application of dehydrocostuslactone and medicine for treating steatohepatitis 国科温州研究院(温州生物材料与工程研究所) 2026-05-12 — — CN claimed
US-20260124203-A1 CHEMICAL SYNTHETIC LETHALITY FOR ANTIMICROBIAL THERAPY THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2026-05-07 — — US claimed
US-20250212873-A1 VOLATILE HDAC INHIBITORS FOR THERAPEUTIC AND PLANT APPLICATIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-07-03 — — US claimed
CN-118731248-B Establishment method and application of reference GC-MS fingerprint of Juanbi decoction substance 广西中医药大学百年乐制药有限公司 2025-05-23 — — CN claimed
CN-119881160-A Method for measuring content of 8 chemical components in spleen-invigorating pill and fingerprint method thereof 上海和黄药业有限公司 2025-04-25 — — CN claimed
CN-119804722-A Method for measuring contents of seven active ingredients in ancient classical prescription of Xiangsha Liujunzi decoction 浙江省肿瘤医院 2025-04-11 — — CN claimed
CN-119462620-B Dehydrocostuslactone derivative and preparation method and application thereof 四川大学华西医院 2025-04-04 — — CN claimed
CN-118717785-B Pharmaceutical composition for preventing and treating scar hyperplasia and preparation method and application thereof 威海人生药业有限公司 2025-03-28 — — CN claimed
CN-115963220-B Identification method of stomach ache pill 广州白云山中一药业有限公司 2025-03-25 — — CN claimed
CN-101007044-B A medicine composition for treating peptic ulcer, preparing method and use thereof UNIV CHENGDU TRAD CN MEDICINE 2010-06-09 — — CN claimed
CN-101559192-A Traditional Chinese medicine granular formulation for warming stomach and regulating middle warmer and quality control method thereof BEIJING ASIA EAST BIO PHARM CO (CN) 2009-10-21 — — CN claimed
CN-101357151-A Method for extracting total lactones from auckandia root and quality control method thereof MINGHAI LI (CN) 2009-02-04 — — CN claimed
CN-101342214-A Banksia rose total lactone medicament composition and preparation method thereof MINGHAI LI (CN) 2009-01-14 — — CN claimed
CN-101342215-A Banksia rose capsule, preparation method and quality control method thereof LI MINGHAI (CN) 2009-01-14 — — CN claimed
CN-101317872-A Traditional Chinese medicine oral preparation for treating functional dyspepsia TIANJIN DANXI NAT MEDICINES IN (CN) 2008-12-10 — — CN claimed
CN-101172135-A Medicament for promoting stomach and intestine function or liveness and application of its components composition RENBING SHI (CN) 2008-05-07 — — CN claimed
CN-101073590-A Muxiang total lactone extract and its production SHI RENBING (CN) 2007-11-21 — — CN claimed
CN-101007044-A A medicine composition for treating peptic ulcer, preparing method and use thereof CHENGDU UNIVERSITY OF TRADITIO (CN) 2007-08-01 — — CN claimed
CN-1981861-A Yixinkang preparation for treating cardiovascular and cerebrovascular diseases and its quality controlling method QIYUANYIDE DRUG INST BEIJING (CN) 2007-06-20 — — CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124203-A1 CHEMICAL SYNTHETIC LETHALITY FOR ANTIMICROBIAL THERAPY COASY, GLO1, FARS2 CYP19A1 1365/4885PKM 1863/4885NLRP3 1348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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