Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | TSHR | P16473 | 7/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.58 |
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL606545 | 0.74 | HRH4 (1.00) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL615146 | 0.72 | MAPT (0.72) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL3876311 | 0.71 | MAPT (0.73) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL13771254 | 0.70 | MAPT (0.68) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL3876308 | 0.70 | MAPT (0.70) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL12256009 | 0.65 | LMNA (1.00) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL15384142 | 0.65 | KIT (0.72) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL16406269 | 0.64 | SMN1; SMN2 (0.67) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL16905930 | 0.64 | HSD17B10 (0.59) | MAPTTSHRHSD17B10HTTHPGD | |
| SCHEMBL18496060 | 0.64 | HRH4 (0.58) | MAPTTSHRHSD17B10HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022062357-A1 | MEDICINE FOR TREATING OR PREVENTING DISEASES RELATED TO ACTIVITY OF LRRK2 KINASE OR ABNORMAL LRRK2 MUTANT KINASE | 广州智睿医药科技有限公司 | 2022-03-31 | — | — | WO | claimed |
| WO-2022062357-A1 | MEDICINE FOR TREATING OR PREVENTING DISEASES RELATED TO ACTIVITY OF LRRK2 KINASE OR ABNORMAL LRRK2 MUTANT KINASE | 广州智睿医药科技有限公司 | 2022-03-31 | — | — | WO | disclosed |