Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28717563 | 1.00 | PPARG (0.52) | PPARGPIM1LMNAL3MBTL1METAP2 | |
| SCHEMBL29557791 | 0.89 | PPARG (0.47) | PPARGPIM1LMNAL3MBTL1METAP2 | |
| SCHEMBL25416754 | 0.89 | PPARG (0.47) | PPARGPIM1LMNAL3MBTL1METAP2 | |
| SCHEMBL29557846 | 0.83 | ILK (0.53) | PPARGLMNATP53KDM4EMAPK1 | |
| SCHEMBL28717580 | 0.83 | ILK (0.53) | PPARGLMNATP53KDM4EMAPK1 | |
| SCHEMBL1315419 | 0.75 | SYK (0.55) | PPARGLMNAMAPK1MAPTMEN1 | |
| Fluoride SCHEMBL13518358 | 0.74 | SYK (0.54) | PPARGLMNAMAPK1MAPTMEN1 | |
| SCHEMBL4676130 | 0.74 | MEN1 (0.37) | PPARGKDM4EMAPK1MAPTMEN1 | |
| SCHEMBL18283748 | 0.73 | RAB9A (0.41) | LMNAL3MBTL1KDM4EMAPK1MAPT | |
| SCHEMBL16764284 | 0.72 | KDR (0.47) | LMNAL3MBTL1TP53KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315796-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114315796-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-04-12 | — | — | CN | disclosed |