Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 5/20 | 0.66 |
| ▸ | PRKCG | P05129 | 5/20 | 0.66 |
| ▸ | PRKCB | P05771 | 5/20 | 0.66 |
| ▸ | PRKCA | P17252 | 5/20 | 0.66 |
| ▸ | PRKCH | P24723 | 5/20 | 0.66 |
| ▸ | PRKCI | P41743 | 5/20 | 0.66 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.66 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.66 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.66 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | PRKACA | P17612 | 4/20 | 0.66 |
| ▸ | PRKACG | P22612 | 4/20 | 0.66 |
| ▸ | PRKACB | P22694 | 4/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902584 | 0.85 | CYP3A4 (0.72) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL29770053 | 0.84 | ROCK2 (0.77) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2962437 | 0.84 | KMT2A (0.64) | SMN1; SMN2MEN1KMT2ATP53TSHR | |
| SCHEMBL10988523 | 0.83 | ROCK2 (0.79) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10985139 | 0.82 | ROCK2 (0.77) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL6916059 | 0.82 | ROCK2 (0.77) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL26584304 | 0.82 | ROCK2 (0.77) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL13497829 | 0.81 | ROCK2 (0.68) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10983918 | 0.81 | PRKD3 (0.67) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL9617961 | 0.81 | ROCK2 (0.77) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866298-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-12-19 | — | — | EP | claimed |
| WO-2006105127-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-10-05 | — | — | WO | claimed |
| US-20060223829-A1 | Hydroxysteroid dehydrogenase inhibitors | TAKEDA SAN DIEGO, INC. | 2006-10-05 | — | — | US | claimed |
| US-7759339-B2 | Hydroxysteroid dehydrogenase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-07-20 | — | — | US | disclosed |
| US-7759339-B2 | Hydroxysteroid dehydrogenase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-07-20 | — | — | US | disclosed |
| US-7759339-B2 | Hydroxysteroid dehydrogenase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-07-20 | — | — | US | disclosed |
| EP-1866298-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105127-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-10-05 | — | — | WO | disclosed |
| US-20060223829-A1 | Hydroxysteroid dehydrogenase inhibitors | TAKEDA SAN DIEGO, INC. | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223829-A1 | Hydroxysteroid dehydrogenase inhibitors | HSD17B1, HSD17B3, HSD17B2 | PRKD3 954/4885PRKCG 1646/4885PRKCB 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.