Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.72 |
| ▸ | PLAU | P00749 | 5/20 | 0.63 |
| ▸ | PLG | P00747 | 4/20 | 0.63 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.58 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.58 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24312939 | 1.00 | CHEK2 (0.72) | CHEK2PLAUPLGDYRK3MAP4K4 | |
| SCHEMBL20912409 | 0.83 | PLAU (0.80) | CHEK2PLAUPLGPRSS1ACHE | |
| SCHEMBL21017221 | 0.79 | ACHE (0.63) | CHEK2DYRK3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL21018152 | 0.78 | ACHE (0.81) | CHEK2PLAUPLGACHEHDAC6 | |
| SCHEMBL14599557 | 0.77 | PLAU (0.77) | CHEK2PLAUPLGPRSS1 | |
| SCHEMBL23566244 | 0.77 | PLAU (0.85) | CHEK2PLAUPLGPRSS1 | |
| SCHEMBL21018108 | 0.77 | ACHE (0.69) | CHEK2DYRK3MAP4K4PIM1RPS6KB1 | |
| SCHEMBL29464816 | 0.77 | PLAU (0.76) | CHEK2PLAUPLGPRSS1 | |
| SCHEMBL5413646 | 0.77 | PLAU (0.76) | CHEK2PLAUPLGPRSS1 | |
| SCHEMBL20912411 | 0.76 | PLAU (0.91) | CHEK2PLAUPLGPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12433872-B2 | Treatment of Acanthamoeba or Balamuthia trophozoites and/or cysts | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2025-10-07 | — | — | US | disclosed |
| US-20220096441-A1 | TREATMENT OF ACANTHAMOEBA OR BALAMUTHIA TROPHOZOITES AND/OR CYSTS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12433872-B2 | Treatment of Acanthamoeba or Balamuthia trophozoites and/or cysts | PKD2, PKD1, MUC1 | CHEK2 241/4885PLAU 959/4885PLG 141/4885 |
| US-20220096441-A1 | TREATMENT OF ACANTHAMOEBA OR BALAMUTHIA TROPHOZOITES AND/OR CYSTS | PKD2, PKD1, MUC1 | CHEK2 241/4885PLAU 959/4885PLG 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.