Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | CCNH | P51946 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29558307 | 0.89 | CDK9 (0.43) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL29558303 | 0.88 | CDK9 (0.46) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL29558484 | 0.85 | CDK9 (0.43) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL24418851 | 0.85 | CDK9 (0.43) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL24418662 | 0.84 | CDK9 (0.51) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL24418616 | 0.83 | CCNT1 (0.47) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL29558148 | 0.83 | CCNT1 (0.64) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL24418615 | 0.80 | CDK9 (0.64) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL24418649 | 0.79 | CCNT1 (0.46) | CCNT1CDK9CDK2CDK1CDK4 | |
| SCHEMBL21877653 | 0.76 | CDK9 (0.48) | CCNT1CDK9CDK2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240422-A1 | COMPOUNDS AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098843-A1 | COMPOUNDS AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2022-05-12 | — | — | WO | disclosed |