Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29558733 | 0.85 | GABRP (0.41) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL29558568 | 0.83 | CDK1 (0.41) | MAPTKDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL29558728 | 0.71 | CDK2 (0.44) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL29558734 | 0.71 | CDK2 (0.44) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL29558396 | 0.70 | KDM4E (0.52) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL29558731 | 0.70 | KDM4E (0.52) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL17053331 | 0.70 | MAPT (0.49) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL16011497 | 0.70 | MAPT (0.49) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL1849673 | 0.70 | KDM4E (0.57) | MAPTKDM4ERAB9ANPC1TDP1 | |
| SCHEMBL30020347 | 0.70 | KDM4E (0.83) | MAPTKDM4ERAB9ANPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380841-A | Tricyclic or dihydroquinazoline compounds as AKT inhibitors | 南京正大天晴制药有限公司 | 2022-04-22 | — | — | CN | disclosed |