Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 9/20 | 0.42 |
| ▸ | CDK4 | P11802 | 7/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.42 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.42 |
| ▸ | CCND1 | P24385 | 6/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.42 |
| ▸ | CDK7 | P50613 | 6/20 | 0.42 |
| ▸ | CDK9 | P50750 | 6/20 | 0.42 |
| ▸ | CCNH | P51946 | 6/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29558731 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL29558728 | 0.85 | CDK2 (0.44) | KDM4EALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL29558734 | 0.85 | CDK2 (0.44) | KDM4EALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL28725447 | 0.83 | NOTUM (0.44) | KDM4EALDH1A1L3MBTL1HPGDCDK2 | |
| SCHEMBL29558432 | 0.83 | NOTUM (0.44) | KDM4EALDH1A1L3MBTL1HPGDCDK2 | |
| SCHEMBL29558869 | 0.74 | CCNA2 (0.44) | KDM4EALDH1A1L3MBTL1CDK2CDK4 | |
| SCHEMBL29558706 | 0.70 | MAPT (0.47) | KDM4EALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL20618262 | 0.70 | ALDH1A1 (0.48) | KDM4EALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL29558733 | 0.70 | GABRP (0.41) | KDM4EALDH1A1L3MBTL1TDP1GAA | |
| SCHEMBL12535924 | 0.70 | KDM4E (0.47) | KDM4EALDH1A1L3MBTL1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380841-A | Tricyclic or dihydroquinazoline compounds as AKT inhibitors | 南京正大天晴制药有限公司 | 2022-04-22 | — | — | CN | disclosed |