Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DNM2 | P50570 | 7/20 | 0.38 |
| ▸ | SPIN4 | Q56A73 | 1/20 | 0.37 |
| ▸ | SPIN3 | Q5JUX0 | 1/20 | 0.37 |
| ▸ | SPIN2B | Q9BPZ2 | 1/20 | 0.37 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1089296 | 0.85 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL1089965 | 0.78 | CXCR4 (0.68) | CXCR4HRH4DNM2 | |
| SCHEMBL1087988 | 0.77 | CXCR4 (0.66) | CXCR4HRH4DNM2 | |
| SCHEMBL9084373 | 0.77 | HRH4 (0.49) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL26616566 | 0.73 | HTT (0.53) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL31376309 | 0.73 | HTT (0.53) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL12963488 | 0.72 | RAF1 (0.56) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9083418 | 0.72 | KMT2A (0.54) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL2948693 | 0.71 | HRH4 (0.55) | ALDH1A1CYP2C19HRH4DNM2 | |
| SCHEMBL1088558 | 0.71 | CXCR4 (0.65) | CXCR4HRH4DNM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120156219-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| US-20100221259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-02 | — | — | US | disclosed |
| US-7759336-B2 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |
| US-20070167459-A1 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-07-19 | — | — | US | disclosed |
| EP-1571146-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | CXCR4, CXCL12, CXCR3 | MEN1 3648/4885KMT2A 3064/4885ALDH1A1 916/4885 |
| US-20070167459-A1 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | CXCR4, CXCL12, CXCR3 | MEN1 3648/4885KMT2A 3064/4885ALDH1A1 916/4885 |
| US-20120156219-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | CXCR4, CXCL12, CXCR3 | MEN1 3648/4885KMT2A 3064/4885ALDH1A1 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.