SCHEMBL29559505

SCHEMBL29559505

Cc1ccc(Cc2cccc(C(F)(F)F)c2)c([N+](=O)[O-])c1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 1/20 0.45
MAPK1 P28482 1/20 0.44
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TSHR P16473 2/20 0.43
CYP3A4 P08684 1/20 0.43
CYP19A1 P11511 1/20 0.41
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40
DAO P14920 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
ACP3 P15309 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22898030 1.00 TDO2 (0.45) TDO2MAPK1MAPTSMN1; SMN2TSHR
SCHEMBL22897963 0.83 TSHR (0.46) MAPK1MAPTSMN1; SMN2TSHRCYP3A4
SCHEMBL6497434 0.82 ALDH1A1 (0.42) MAPK1MAPTSMN1; SMN2CYP3A4CYP19A1
SCHEMBL10654709 0.81 TSHR (0.53) MAPTSMN1; SMN2TSHRCYP3A4NPC1
SCHEMBL22897958 0.77 HTR2A (0.49) MAPK1MAPTTSHRCYP3A4HTR2A
SCHEMBL29559521 0.77 HTR2A (0.49) MAPK1MAPTTSHRCYP3A4HTR2A
SCHEMBL22898033 0.76 TDO2 (0.47) TDO2MAPK1MAPTSMN1; SMN2TSHR
SCHEMBL22897910 0.75 TSHR (0.50) MAPK1MAPTSMN1; SMN2TSHRCYP3A4
SCHEMBL3781829 0.74 HTR2A (0.41) MAPK1MAPTHTR2AHTR2CHTR2B
SCHEMBL22897891 0.74 CYP19A1 (0.49) MAPTSMN1; SMN2TSHRCYP3A4CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114072000-A Molecules having certain pesticidal effects and intermediates, compositions and methods related thereto 科迪华农业科技有限责任公司 2022-02-18 CN disclosed