Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12606489 | 1.00 | OPRK1 (0.47) | OPRK1ADORA1KMT2AKDM4ENPC1 | |
| SCHEMBL5036890 | 0.92 | KMT2A (0.48) | KMT2AALDH1A1MEN1LMNA | |
| SCHEMBL2831248 | 0.87 | MEN1 (0.54) | ADORA1KMT2ANPC1ALDH1A1MAPK1 | |
| SCHEMBL8576896 | 0.87 | MEN1 (0.54) | ADORA1KMT2ANPC1ALDH1A1MAPK1 | |
| SCHEMBL2831250 | 0.87 | MEN1 (0.54) | ADORA1KMT2ANPC1ALDH1A1MAPK1 | |
| SCHEMBL4532631 | 0.84 | ADORA1 (0.50) | ADORA1KMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL4532628 | 0.84 | ADORA1 (0.50) | ADORA1KMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8542919 | 0.80 | MEN1 (0.47) | ADORA1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL8542921 | 0.80 | MEN1 (0.47) | ADORA1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL4579407 | 0.78 | KMT2A (0.56) | ADORA1KMT2AALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983401-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-04-20 | — | — | EP | disclosed |