Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | ACLY | P53396 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561557 | 0.91 | SIRT6 (0.73) | SIRT6ALDH1A1LMNAPKMGPR27 | |
| SCHEMBL24625533 | 0.89 | SIRT6 (0.67) | SIRT6ALDH1A1LMNAPKMGPR27 | |
| SCHEMBL29562488 | 0.84 | SIRT6 (0.71) | SIRT6ALDH1A1LMNAGPR27PSEN1 | |
| SCHEMBL23260707 | 0.84 | SIRT6 (0.68) | SIRT6ALDH1A1LMNAPKMGPR27 | |
| SCHEMBL29561258 | 0.83 | SIRT6 (1.00) | SIRT6ALDH1A1GPR27ACLY | |
| SCHEMBL23260622 | 0.83 | SIRT6 (0.70) | SIRT6PKMACLY | |
| SCHEMBL23261498 | 0.83 | SIRT6 (0.84) | SIRT6GPR27ACLYIDH1 | |
| SCHEMBL23261499 | 0.83 | SIRT6 (0.75) | SIRT6ALDH1A1PKMGPR27CYP3A4 | |
| SCHEMBL23260610 | 0.83 | SIRT6 (0.84) | SIRT6GPR27ACLYIDH1 | |
| SCHEMBL23260612 | 0.82 | SIRT6 (0.80) | SIRT6ALDH1A1LMNAGPR27CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384694-B | SIRT6 small-molecule agonist and application thereof | 上海爱乐维生物科技有限公司 | 2022-04-05 | — | — | CN | disclosed |