Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | PPOX | P50336 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22831892 | 1.00 | LMNA (0.40) | LMNAPOLBSMN1; SMN2TDP1EPAS1 | |
| SCHEMBL22831965 | 0.90 | LMNA (0.35) | LMNAPOLBSMN1; SMN2TDP1MAPT | |
| SCHEMBL29562048 | 0.90 | LMNA (0.35) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL29561992 | 0.90 | LMNA (0.35) | LMNAPOLBSMN1; SMN2TDP1MAPT | |
| SCHEMBL22832036 | 0.90 | LMNA (0.35) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL22832147 | 0.87 | GRM6 (0.36) | EPAS1 | |
| SCHEMBL29562072 | 0.85 | GRM6 (0.35) | LMNAPOLBSMN1; SMN2TDP1MAPT | |
| SCHEMBL22832130 | 0.85 | GRM6 (0.35) | LMNAPOLBSMN1; SMN2TDP1MAPT | |
| SCHEMBL22832025 | 0.83 | HSPB1 (0.34) | LMNAPOLBSMN1; SMN2TDP1MAPT | |
| SCHEMBL29562112 | 0.83 | HSPB1 (0.34) | LMNAPOLBSMN1; SMN2TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990437-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | Array Biopharma, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |