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Leusa

Leusa

SCHEMBL29562511

CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ LARS1 Q9P2J5 2/20 1.00
▸ SARS1 P49591 1/20 0.83
▸ TARS1 P26639 2/20 0.82
▸ MARS1 P56192 1/20 0.79
▸ IARS1 P41252 1/20 0.79
▸ RARS1 P54136 1/20 0.73
▸ HARS1 P12081 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alasa SCHEMBL4320823 0.92 TARS1 (0.87) LARS1SARS1TARS1MARS1IARS1
Alasa SCHEMBL21067643 0.92 TARS1 (0.87) LARS1SARS1TARS1MARS1IARS1
Alasa SCHEMBL29531843 0.92 TARS1 (0.87) LARS1SARS1TARS1MARS1IARS1
SCHEMBL30270578 0.91 SARS1 (0.85) LARS1SARS1TARS1MARS1IARS1
SCHEMBL178823 0.91 SARS1 (0.85) LARS1SARS1TARS1MARS1IARS1
SCHEMBL178824 0.91 SARS1 (0.85) LARS1SARS1TARS1MARS1IARS1
SCHEMBL3187665 0.91 SARS1 (0.87) LARS1SARS1TARS1MARS1IARS1
SCHEMBL21067959 0.91 SARS1 (1.00) LARS1SARS1TARS1MARS1IARS1
SCHEMBL21068060 0.91 SARS1 (0.87) LARS1SARS1TARS1MARS1IARS1
SCHEMBL3187637 0.91 SARS1 (0.87) LARS1SARS1TARS1MARS1IARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114262690-A Clonal strains of attenuated vaccinia virus and methods of use thereof 吉恩勒克斯公司 2022-04-01 — — CN disclosed
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