Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 19/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | TEC | P42680 | 2/20 | 0.54 |
| ▸ | BMX | P51813 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | ITK | Q08881 | 2/20 | 0.54 |
| ▸ | TXK | P42681 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29785261 | 1.00 | ALOX15 (0.58) | ALOX15MAPK1CASP1CASP7HSD17B10 | |
| SCHEMBL20303901 | 0.82 | BTK (0.52) | BTKJAK2 | |
| SCHEMBL20303898 | 0.82 | BTK (0.52) | BTKJAK2 | |
| SCHEMBL123720 | 0.80 | BTK (0.57) | BTKJAK2LCKTECBMX | |
| SCHEMBL19715436 | 0.80 | BTK (0.57) | BTKJAK2LCKTECBMX | |
| SCHEMBL19279113 | 0.80 | BTK (0.57) | BTKJAK2LCKTECBMX | |
| SCHEMBL19279346 | 0.78 | ALOX15 (0.57) | ALOX15MAPK1CASP1CASP7HSD17B10 | |
| SCHEMBL147737 | 0.75 | ALOX15 (0.53) | ALOX15MAPK1CASP1CASP7HSD17B10 | |
| SCHEMBL29785257 | 0.74 | ALDH1A1 (0.64) | ALOX15MAPK1CASP1CASP7HSD17B10 | |
| SCHEMBL150478 | 0.74 | ALOX15 (1.00) | ALOX15MAPK1CASP1CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081512-A1 | COMPOSITIONS AND METHODS OF TREATMENT OF NEUROINFLAMMATORY DISEASES WITH BRUTON'S TYROSINE KINASE INHIBITORS | SYNUBI PHARMACEUTICALS LLC (US) | 2022-04-21 | — | — | WO | disclosed |