SCHEMBL29565387

SCHEMBL29565387

COc1cc2c3c(c4c(c2cc1N1CCC(O)CC1)-c1ccccc1C4(C)C)C=CC(c1ccc(F)cc1)(c1ccc(N2CCOCC2)cc1)O3

nearest known ligand 0.31

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
STK10 O94804 1/20 0.31
SLK Q9H2G2 1/20 0.31
PIK3CA P42336 1/20 0.31
PDK2 Q15119 2/20 0.31
IDO1 P14902 1/20 0.31
MAPT P10636 2/20 0.30
NPSR1 Q6W5P4 1/20 0.30
HSD17B10 Q99714 1/20 0.30
KDM4E B2RXH2 1/20 0.30
NPC1 O15118 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
HPGD P15428 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23800851 1.00 STK10 (0.31) STK10SLKPIK3CAPDK2IDO1
SCHEMBL29453303 0.95 PIK3CA (0.32) STK10SLKPIK3CAPDK2
SCHEMBL1077782 0.95 PIK3CA (0.32) STK10SLKPIK3CAPDK2
SCHEMBL29565453 0.92 PAX8 (0.32)
SCHEMBL23800899 0.92 PAX8 (0.32)
SCHEMBL23800786 0.91 TNK2 (0.31) MAPTALDH1A1HPGD
SCHEMBL29565404 0.91 TNK2 (0.31) MAPTALDH1A1HPGD
SCHEMBL25844425 0.91 STK10 (0.35) STK10SLKPIK3CAPDK2MAPT
SCHEMBL11995963 0.90 PIK3CA (0.35) STK10SLKPIK3CAPDK2MAPT
SCHEMBL25605060 0.90 PIK3CA (0.35) STK10SLKPIK3CAPDK2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12111443-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-10-08 US claimed
US-20240287379-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2024-08-29 US claimed
CN-115605529-B Photochromic polydiorganosiloxane vinyl cross-linking agent 爱尔康公司 2024-03-26 CN claimed
EP-4313567-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-02-07 EP claimed
EP-4304842-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
EP-4304843-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
EP-4158392-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2023-04-05 EP claimed
EP-4118134-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS Alcon Inc. (CH) 2023-01-18 EP claimed
CN-115605529-A Photochromic polydiorganosiloxane ethylene crosslinkers 爱尔康公司(CH) 2023-01-13 CN claimed
WO-2022208450-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-10-06 WO claimed
WO-2022189941-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-15 WO claimed
WO-2022189940-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES ALCON INC. (CH) 2022-09-15 WO claimed
US-20220281193-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES ALCON INC. (CH) 2022-09-08 US claimed
US-20240287379-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2024-08-29 US disclosed
US-11999908-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-06-04 US disclosed
CN-115605529-B Photochromic polydiorganosiloxane vinyl cross-linking agent 爱尔康公司 2024-03-26 CN disclosed
WO-2022189941-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-15 WO disclosed
WO-2022189940-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES ALCON INC. (CH) 2022-09-15 WO disclosed
US-20220281193-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES ALCON INC. (CH) 2022-09-08 US disclosed
WO-2022090967-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-05-05 WO disclosed