SCHEMBL25844425

SCHEMBL25844425

COc1cc2c3c(c4c(c2cc1N1CCOCC1)-c1ccccc1C4(C)C)C=CC(c1ccc(N2CCOCC2)cc1)(c1ccc(N2CCOCC2)cc1)O3

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK10 O94804 1/20 0.35
SLK Q9H2G2 1/20 0.35
PIK3CA P42336 1/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPT P10636 3/20 0.34
LMNA P02545 2/20 0.34
KDM4E B2RXH2 2/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PRKDC P78527 1/20 0.33
FYN P06241 1/20 0.31
PDK2 Q15119 2/20 0.31
TNK2 Q07912 1/20 0.31
HIF1A Q16665 1/20 0.31
DRD2 P14416 1/20 0.31
DRD4 P21917 1/20 0.31
HRH2 P25021 1/20 0.31
HRH1 P35367 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25605060 0.98 PIK3CA (0.35) STK10SLKPIK3CAALDH1A1MAPT
SCHEMBL11995963 0.98 PIK3CA (0.35) STK10SLKPIK3CAALDH1A1MAPT
SCHEMBL25716358 0.97 ALDH1A1 (0.34) STK10SLKPIK3CAALDH1A1MAPT
SCHEMBL25605051 0.95 DRD2 (0.34) STK10SLKPIK3CAALDH1A1MAPT
SCHEMBL25605055 0.95 STK10 (0.36) STK10SLKPIK3CAALDH1A1MAPT
SCHEMBL1188005 0.94 ATM (0.33) PIK3CAALDH1A1MAPTNPC1RAB9A
SCHEMBL11995965 0.94 ATM (0.33) PIK3CAALDH1A1MAPTNPC1RAB9A
SCHEMBL23800764 0.94 HTR7 (0.35) STK10SLKPIK3CAALDH1A1MAPT
SCHEMBL29565425 0.94 HTR7 (0.35) STK10SLKPIK3CAALDH1A1MAPT
SCHEMBL2018673 0.94 DRD2 (0.32) ALDH1A1MAPTLMNASMN1; SMN2DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4269532-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-11-01 EP disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 STK10 1116/4885SLK 2041/4885PIK3CA 3076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.