SCHEMBL29565653

SCHEMBL29565653

COc1cc(C=CC=CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.85
CYP1A2 P05177 2/20 0.85
ALOX5 P09917 2/20 0.85
NFKB1 P19838 2/20 0.85
HSD11B1 P28845 2/20 0.85
STAT3 P40763 2/20 0.85
NFKB2 Q00653 2/20 0.85
RELA Q04206 2/20 0.85
NFE2L2 Q16236 2/20 0.85
APP P05067 3/20 0.68
KDM4E B2RXH2 2/20 0.68
CA12 O43570 2/20 0.68
CA1 P00915 2/20 0.68
CA2 P00918 2/20 0.68
CA3 P07451 2/20 0.68
PKM P14618 2/20 0.68
CA4 P22748 2/20 0.68
CA6 P23280 2/20 0.68
CA5A P35218 2/20 0.68
SNCA P37840 2/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3294809 1.00 CYP2D6 (0.85) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL3294805 1.00 CYP2D6 (0.85) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL29566264 0.95 STAT3 (0.76) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL1493283 0.92 CYP2D6 (1.00) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL29478095 0.92 CYP2D6 (1.00) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL1493282 0.92 CYP2D6 (1.00) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL30668505 0.92 CYP2D6 (1.00) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL17014665 0.90 NFKB1 (0.74) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL2744233 0.88 CYP2D6 (0.91) CYP2D6CYP1A2ALOX5NFKB1HSD11B1
SCHEMBL19824721 0.88 CYP2D6 (0.91) CYP2D6CYP1A2ALOX5NFKB1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022090877-A1 METAL COMPLEXES OF DIARYLHEPTANOIDS AND ITS DERIVATIVES ARJUNA NATURAL PRIVATE LIMITED (IN) 2022-05-05 WO disclosed