Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 5/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309726 | 1.00 | HTR1A (0.43) | HTR1AHTR7BRD4TSHRSMN1; SMN2 | |
| SCHEMBL24309574 | 0.90 | BRD4 (0.41) | HTR1AHTR7BRD4TSHRSMN1; SMN2 | |
| SCHEMBL29567022 | 0.90 | BRD4 (0.41) | HTR1AHTR7BRD4TSHRSMN1; SMN2 | |
| SCHEMBL29567731 | 0.88 | BRD4 (0.38) | BRD4TSHRSMN1; SMN2KMT2ARXFP1 | |
| SCHEMBL24310817 | 0.88 | BRD4 (0.38) | BRD4TSHRSMN1; SMN2KMT2ARXFP1 | |
| SCHEMBL24309255 | 0.85 | DRD2 (0.36) | HTR1AHTR7BRD4DRD2HTR6 | |
| SCHEMBL29566539 | 0.85 | DRD2 (0.36) | HTR1AHTR7BRD4DRD2HTR6 | |
| SCHEMBL24309983 | 0.84 | HTR1A (0.39) | HTR1AHTR7BRD4TSHRSMN1; SMN2 | |
| SCHEMBL26807637 | 0.84 | HTR1A (0.40) | HTR1AHTR7BRD4TSHRSMN1; SMN2 | |
| SCHEMBL24309256 | 0.84 | HTR1A (0.39) | HTR1AHTR7TSHRKMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |