Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 10/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26806504 | 1.00 | PIK3CG (0.41) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL26811264 | 0.92 | PIK3CG (0.38) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL26811236 | 0.88 | PIK3CG (0.38) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL26811274 | 0.88 | PIK3CG (0.40) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL24310778 | 0.87 | HTR1A (0.40) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL26811267 | 0.86 | PIK3CG (0.42) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL26806550 | 0.86 | TSHR (0.39) | PIK3CGPIK3CDPIK3CBHTR1AHTR7 | |
| SCHEMBL26806541 | 0.86 | NUDT1 (0.37) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL26806539 | 0.86 | HTR1A (0.36) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A | |
| SCHEMBL26811255 | 0.85 | HTR1A (0.38) | PIK3CGPIK3CDPIK3CBPIK3CAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |