Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | GPR39 | O43194 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309644 | 1.00 | POLB (0.42) | POLBPGRTSHRSMN1; SMN2PIK3C2B | |
| SCHEMBL26810769 | 0.91 | TSHR (0.50) | PGRTSHRSMN1; SMN2MAPTGPR39 | |
| SCHEMBL29566936 | 0.88 | SMN1; SMN2 (0.40) | POLBPGRTSHRSMN1; SMN2PIK3C2B | |
| SCHEMBL24310351 | 0.88 | SMN1; SMN2 (0.40) | POLBPGRTSHRSMN1; SMN2PIK3C2B | |
| SCHEMBL24309603 | 0.86 | POLB (0.45) | POLBPGRTSHRSMN1; SMN2PIK3C2B | |
| SCHEMBL24309297 | 0.85 | PGR (0.52) | PGRMAPTF2PRSS1PRSS2 | |
| SCHEMBL29567154 | 0.85 | PGR (0.52) | PGRMAPTF2PRSS1PRSS2 | |
| SCHEMBL29566697 | 0.85 | TSHR (0.38) | POLBTSHRSMN1; SMN2PIK3C2BPIK3C2G | |
| SCHEMBL24309704 | 0.85 | TSHR (0.38) | POLBTSHRSMN1; SMN2PIK3C2BPIK3C2G | |
| SCHEMBL26806726 | 0.84 | POLB (0.43) | POLBPGRTSHRSMN1; SMN2PIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |