Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309704 | 1.00 | TSHR (0.38) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL24310577 | 0.90 | SMN1; SMN2 (0.40) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL29566688 | 0.90 | SMN1; SMN2 (0.40) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL29566936 | 0.88 | SMN1; SMN2 (0.40) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL24310351 | 0.88 | SMN1; SMN2 (0.40) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL24309706 | 0.87 | LMNA (0.42) | MAPTKDM1AKDM4ELMNAMEN1 | |
| SCHEMBL29567003 | 0.86 | SMN1; SMN2 (0.36) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL24309272 | 0.86 | SMN1; SMN2 (0.36) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL24309644 | 0.85 | POLB (0.42) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB | |
| SCHEMBL29566684 | 0.85 | POLB (0.42) | TSHRSMN1; SMN2PIK3C2BPIK3C2GPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |