Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.33 |
| ▸ | FEN1 | P39748 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309523 | 1.00 | POLB (0.36) | POLBNUDT1MAPTPIK3C2BPIK3C2G | |
| SCHEMBL26806787 | 0.89 | PTGS1 (0.40) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806784 | 0.88 | POLB (0.41) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806794 | 0.87 | POLB (0.38) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806791 | 0.86 | POLB (0.36) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806783 | 0.84 | POLB (0.41) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26808381 | 0.83 | HTR1A (0.41) | SMN1; SMN2TSHR | |
| SCHEMBL29566529 | 0.83 | HTR1A (0.41) | SMN1; SMN2TSHR | |
| SCHEMBL26806788 | 0.83 | LMNA (0.37) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806726 | 0.83 | POLB (0.43) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |