Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | ULK1 | O75385 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309919 | 1.00 | FGFR1 (0.40) | FGFR1EGFRKDRF10ULK1 | |
| SCHEMBL26811489 | 0.92 | FGFR1 (0.38) | FGFR1EGFRKDRF10ULK1 | |
| SCHEMBL29567325 | 0.91 | FGFR1 (0.39) | FGFR1EGFRKDRHPGDSMN1; SMN2 | |
| SCHEMBL24309822 | 0.91 | FGFR1 (0.39) | FGFR1EGFRKDRHPGDSMN1; SMN2 | |
| SCHEMBL29567228 | 0.87 | HTR1A (0.40) | FGFR1EGFRKDRHPGDSMN1; SMN2 | |
| SCHEMBL24309861 | 0.87 | HTR1A (0.40) | FGFR1EGFRKDRHPGDSMN1; SMN2 | |
| SCHEMBL29566629 | 0.86 | GPR119 (0.40) | HTR1AHTR7 | |
| SCHEMBL26808782 | 0.86 | GPR119 (0.40) | HTR1AHTR7 | |
| SCHEMBL24309774 | 0.86 | HTR1A (0.34) | FGFR1EGFRKDRFGFR3PTK2 | |
| SCHEMBL29566573 | 0.86 | HTR1A (0.34) | FGFR1EGFRKDRFGFR3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |