Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310444 | 1.00 | NAT1 (0.38) | NAT1SMN1; SMN2TSHRPOLBMAPT | |
| SCHEMBL26806726 | 0.93 | POLB (0.43) | NAT1SMN1; SMN2TSHRPOLBMAPT | |
| SCHEMBL26806752 | 0.92 | NPY5R (0.39) | NAT1SMN1; SMN2TSHRPOLBMAPT | |
| SCHEMBL26806725 | 0.92 | PGR (0.43) | SMN1; SMN2TSHRPOLBALDH1A1LMNA | |
| SCHEMBL26806723 | 0.90 | PGR (0.39) | SMN1; SMN2TSHRPOLBMAPTKMT2A | |
| SCHEMBL26806771 | 0.90 | PGR (0.41) | POLBMAPTPIK3C2BPIK3C2G | |
| SCHEMBL26806627 | 0.89 | CHEK1 (0.36) | SMN1; SMN2TSHRPOLBMAPTALDH1A1 | |
| SCHEMBL26806721 | 0.88 | PIK3C2B (0.39) | SMN1; SMN2TSHRPOLBMAPTALDH1A1 | |
| SCHEMBL26806728 | 0.88 | PGR (0.42) | SMN1; SMN2TSHRPOLBMAPTPIK3C2B | |
| SCHEMBL26806719 | 0.88 | HTR6 (0.43) | SMN1; SMN2TSHRPOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |