Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.33 |
| ▸ | HTR7 | P34969 | 5/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.30 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310103 | 1.00 | HTR1A (0.33) | HTR1AHTR7PTK2TNK2SLC8A1 | |
| SCHEMBL24309499 | 0.93 | HTR1A (0.34) | HTR1AHTR7TNK2SLC8A1 | |
| SCHEMBL29566422 | 0.93 | HTR1A (0.34) | HTR1AHTR7TNK2SLC8A1 | |
| SCHEMBL29566725 | 0.91 | HTR1A (0.34) | HTR1AHTR7SLC8A1 | |
| SCHEMBL24310056 | 0.91 | HTR1A (0.34) | HTR1AHTR7SLC8A1 | |
| SCHEMBL24309541 | 0.88 | HTR1A (0.34) | HTR1AHTR7PTK2SLC8A1 | |
| SCHEMBL29567193 | 0.87 | GHSR (0.34) | HTR1AHTR7PTK2TNK2 | |
| SCHEMBL24310165 | 0.87 | GHSR (0.34) | HTR1AHTR7PTK2TNK2 | |
| SCHEMBL24310187 | 0.84 | RAD52 (0.36) | HTR1AHTR7 | |
| SCHEMBL29566963 | 0.84 | RAD52 (0.36) | HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |