Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 4/20 | 0.32 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26651231 | 1.00 | HTR6 (0.32) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL26811673 | 0.89 | HTR1A (0.33) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL24310779 | 0.88 | HTR1A (0.36) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL24310154 | 0.85 | — | — | |
| SCHEMBL26811965 | 0.85 | HTR6 (0.33) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL29566783 | 0.84 | HTR6 (0.34) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL24309538 | 0.84 | HTR6 (0.34) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL26808486 | 0.83 | HTR1A (0.34) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL24309528 | 0.82 | HTR1A (0.37) | HTR6HTR1AHTR7DRD2DRD4 | |
| SCHEMBL29566490 | 0.82 | CTSC (0.34) | HTR6HTR1AHTR7HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |