Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | TACR1 | P25103 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 2/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310530 | 1.00 | RAD52 (0.34) | RAD52BRD4TACR1HTR1AHTR7 | |
| SCHEMBL24310777 | 0.92 | HTR1A (0.38) | RAD52BRD4TACR1HTR1AHTR7 | |
| SCHEMBL29566715 | 0.92 | HTR1A (0.38) | RAD52BRD4TACR1HTR1AHTR7 | |
| SCHEMBL29566963 | 0.92 | RAD52 (0.36) | RAD52BRD4TACR1HTR1AHTR7 | |
| SCHEMBL24310187 | 0.92 | RAD52 (0.36) | RAD52BRD4TACR1HTR1AHTR7 | |
| SCHEMBL24309520 | 0.90 | SCN9A (0.35) | BRD4HTR1AHTR7JAK2 | |
| SCHEMBL29566590 | 0.90 | SCN9A (0.35) | BRD4HTR1AHTR7JAK2 | |
| SCHEMBL24310497 | 0.89 | RAD52 (0.36) | RAD52BRD4MAP4K1IGF1REGFR | |
| SCHEMBL29567138 | 0.89 | RAD52 (0.36) | RAD52BRD4MAP4K1IGF1REGFR | |
| SCHEMBL29567137 | 0.89 | RAD52 (0.36) | RAD52BRD4MAP4K1IGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |