Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567138 | 1.00 | RAD52 (0.36) | RAD52IGF1RTNK2BRD4PTK2 | |
| SCHEMBL24310497 | 1.00 | RAD52 (0.36) | RAD52IGF1RTNK2BRD4PTK2 | |
| SCHEMBL29566715 | 0.90 | HTR1A (0.38) | RAD52IGF1RTNK2BRD4PTK2 | |
| SCHEMBL24310777 | 0.90 | HTR1A (0.38) | RAD52IGF1RTNK2BRD4PTK2 | |
| SCHEMBL29566963 | 0.90 | RAD52 (0.36) | RAD52BRD4JAK3MAP4K1 | |
| SCHEMBL24310187 | 0.90 | RAD52 (0.36) | RAD52BRD4JAK3MAP4K1 | |
| SCHEMBL24310530 | 0.89 | RAD52 (0.34) | RAD52IGF1RBRD4EGFRMAP4K1 | |
| SCHEMBL29566997 | 0.89 | RAD52 (0.34) | RAD52IGF1RBRD4EGFRMAP4K1 | |
| SCHEMBL24310787 | 0.88 | AXL (0.33) | RAD52BRD4EGFRJAK3INSR | |
| SCHEMBL29567201 | 0.88 | AXL (0.33) | RAD52BRD4EGFRJAK3INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |