Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309269 | 1.00 | POLB (0.43) | POLBMAPTPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL24309253 | 0.86 | POLB (0.37) | POLBMAPTPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL26806783 | 0.85 | POLB (0.41) | POLBMAPTPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL26806784 | 0.85 | POLB (0.41) | POLBMAPTPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL26806758 | 0.85 | MEN1 (0.39) | POLBMAPTSMN1; SMN2TSHRPGR | |
| SCHEMBL26806749 | 0.85 | POLB (0.38) | POLBMAPTALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL26806771 | 0.84 | PGR (0.41) | POLBMAPTHTR6PGRPIK3C2B | |
| SCHEMBL26806726 | 0.84 | POLB (0.43) | POLBMAPTPKMSMN1; SMN2HTR6 | |
| SCHEMBL26806595 | 0.84 | LMNA (0.47) | MAPTALDH1A1PGRKMT2AKDM1A | |
| SCHEMBL24309272 | 0.83 | SMN1; SMN2 (0.36) | POLBMAPTALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |