Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26812715 | 1.00 | AR (0.47) | ARMEN1KMT2AKDM1AMAOA | |
| SCHEMBL26812660 | 0.83 | MAPT (0.58) | MEN1KMT2ATDP1CA2MMP1 | |
| SCHEMBL24309652 | 0.82 | TDP1 (0.50) | MEN1KMT2ATDP1MAPK1MAPT | |
| SCHEMBL29567152 | 0.82 | TDP1 (0.50) | MEN1KMT2ATDP1MAPK1MAPT | |
| SCHEMBL24310225 | 0.82 | MAPT (0.52) | MEN1KMT2ATDP1MAPK1MAPT | |
| SCHEMBL26812645 | 0.81 | PGR (0.61) | ARMEN1KMT2AKDM1ATDP1 | |
| SCHEMBL26812683 | 0.80 | MAPT (0.48) | MEN1KMT2ATDP1MMP1MMP2 | |
| SCHEMBL26812913 | 0.80 | ACLY (0.48) | MEN1KMT2ATDP1MAPK1MAPT | |
| SCHEMBL26806813 | 0.80 | MAPT (0.61) | MEN1KMT2ATDP1MAPK1MAPT | |
| SCHEMBL24310218 | 0.78 | TDP1 (0.46) | MEN1KMT2ATDP1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |