Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20501210 | 1.00 | SIRT6 (0.44) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL29679513 | 0.87 | SIRT6 (0.48) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1640894 | 0.87 | SIRT6 (0.48) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2895340 | 0.86 | PDGFRB (0.50) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL18953141 | 0.83 | SIRT6 (0.45) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL29611567 | 0.83 | SIRT6 (0.45) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL13107196 | 0.83 | PDGFRB (0.51) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL11922583 | 0.82 | TDP1 (0.50) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2609072 | 0.82 | SIRT6 (0.44) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL26090914 | 0.82 | POLB (0.49) | SIRT6PDGFRBFGFR1PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022074589-A1 | CARBOXYLIC DIARYLTHIAZEPINEAMINES AND USES THEREFOR | KURES, INC. (US) | 2022-04-14 | — | — | WO | disclosed |