Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | FER | P16591 | 1/20 | 0.57 |
| ▸ | LTK | P29376 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518105 | 1.00 | MAPT (0.60) | MAPTGAALRRK2ACVR1PDGFRA | |
| SCHEMBL518104 | 1.00 | MAPT (0.60) | MAPTGAALRRK2ACVR1PDGFRA | |
| SCHEMBL6279537 | 0.80 | MAPT (0.50) | MAPTGAALRRK2ACVR1PDGFRA | |
| SCHEMBL6358112 | 0.80 | MAPT (0.50) | MAPTGAALRRK2ACVR1PDGFRA | |
| SCHEMBL13629303 | 0.79 | CYP1A2 (0.55) | MAPTGAALRRK2ACVR1PDGFRA | |
| SCHEMBL13629301 | 0.79 | CYP1A2 (0.55) | MAPTGAALRRK2ACVR1PDGFRA | |
| SCHEMBL2420711 | 0.77 | LRRK2 (0.90) | MAPTLRRK2ACVR1PDGFRAFER | |
| SCHEMBL366728 | 0.77 | — | — | |
| Iminostilbene SCHEMBL75288 | 0.77 | MAPT (1.00) | MAPTGAALRRK2ACVR1PDGFRA | |
| Iminostilbene SCHEMBL29926907 | 0.77 | MAPT (1.00) | MAPTGAALRRK2ACVR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114394960-A | Dibenzocyclooctyne-tetraethylene glycol-active ester compound, preparation method and application | 宜昌博仁凯润药业有限公司 | 2022-04-26 | — | — | CN | disclosed |